Can your lube affect your chances of getting pregnant? Yes some lubricants can make it harder for sperm to reach the egg. Look for sperm safe or fertility friendly formulas that mimic your Fertility Lubricants: How to Support Your Sperm when TTC Mira Fertility Shop When trying to conceive, choosing the right lubricant matters. Some common products like oil based lubricants, petroleum jelly, saliva, and regular lubricants may harm sperm and reduce fertility chances. Instead, opt for fertility friendly, Amazon.com: LUBELIFE Fertility Lube Water Based Personal Lubricant for Men, Women & Couples Pregnancy Must Haves, Sperm Friendly, Vegan, Travel Size, 2 Fl Oz : Health & Household Do Lubricants Affect Pregnancy Chances? Many couples wonder if lubricants can prevent conception. Oil based lubricants (like Vaseline, coconut oil, creams, lotions) can slow down sperm movement and reduce pregnancy chances. Lube and fertility: Can lube impact your chances of conceiving?